Publications

Key Publications

Wang XF, Yang SA, Gong S, Chang CH, Portilla JM, Chatterjee D, Irianto J, Bao H, Huang YC, Deng WM. 2021. Polyploid mitosis and depolyploidization promote chromosomal instability and tumor progression in a Notch-induced tumor model. Dev Cell. 56(13):1976-1988.e4 PubMed

Jevitt A, Chatterjee D, Xie G, Wang XF, Otwell T, Huang YC, Deng WM. 2020. Single-cell RNA sequencing of adult Drosophila ovary identifies transcriptional programs governing oogenesis. PLoS Biol. 18(4):e3000538. PubMed

Yang SA, Portilla JM, Mihailovic S, Huang YC, Deng WM. 2019. Oncogenic Notch Triggers Neoplastic Tumorigenesis in a Transition-Zone-like Tissue Microenvironment. Dev Cell. 49 (3), 461-472.e5. PubMed

Yang SA, Deng WM. 2018. Serrate-Notch Signaling Regulates the Size of the Progenitor Cell Pool in Drosophila Imaginal Rings. Genetics. 209(3):829–843. PubMed

Xie G, Chen H, Jia D, Shu Z, Palmer WH, Huang YC, Zeng X, Hou SX, Jiao R, Deng WM. 2017. The SWI/SNF complex protein Snr1 is a tumor suppressor in Drosophila imaginal tissues. Cancer Res. 15;77(4):862-873. PubMed

Tamori Y, Suzuki E, Deng WM. 2016. Epithelial Tumors Originate in Tumor Hotspots, a Tissue-Intrinsic Microenvironment. PLoS Biol. 1;14(9):e1002537. PubMed

Tamori Y, Deng WM. 2013. Tissue Repair through Cell Competition and Compensatory Cellular Hypertrophy in Postmitotic Epithelia. Developmental Cell. 25(4): 350-363. PubMed

Sun J, Smith L, Armento A, Deng WM. 2008. Regulation of the endocycle/gene amplification switch by Notch and ecdysone signaling. The Journal of Cell Biology. 182(5): 885-96. PubMed

Find Deng’s Publications on PubMed

All Research Articles

Teng Z, Yang L, Zhang Q, Chen Y, Wang X, Zheng Y, Tian A, Tian D, Lin Z, Deng WM, Liu H. 2024. Topoisomerase I is an Evolutionarily Conserved Key Regulator for Satellite DNA Transcription. Nat Commun. doi.org/10.1038/s41467-024-49567-5

Sun J, Liu WK, Ellsworth C, Sun Q, Pan YF, Huang YC, Deng WM. 2023. Integrating lipid metabolism, pheromone production and perception by Fruitless and Hepatocyte Nuclear Factor 4. Science Advances. doi:10.1126/sciadv.adf6254

Huang Z, Wang W, Xu P, Gong S, Hu Y, Liu Y, Su F, Anjum KM, Deng WM, Yang S, Liu J, Jiao R, Chen J. 2023. Drosophila Ectoderm-expressed 4 modulates JAK/STAT pathway and protects flies against Drosophila C virus infection. Front Immunol. doi: 10.3389/fimmu.2023.1135625

Chatterjee D, Cong F, Wang XF, Costa C.A.M, Huang YC, Deng WM. 2023. Cell polarity opposes Jak/STAT-mediated Escargot activation that drives intratumor heterogeneity in a Drosophila tumor model. Cell Reports. doi: 10.1016/j.celrep.2023.112061

Chatterjee D, Costa C.A.M, Wang XF, Jevitt A, Huang YC, Deng WM. 2022. Single-cell transcriptomics identifies Keap1-Nrf2 regulated collective invasion in a Drosophila tumor model. Elife. doi: 10.7554/eLife.80956

Jia D, Jevitt A, Huang YC, Ramos B, Deng WM. 2022. Developmental regulation of epithelial cell cuboidal-to-squamous transition in Drosophila follicle cells. Dev Biol. doi: 10.1016/j.ydbio.2022.09.001

Tian A, Morejon V, Kohoutek S, Huang YC, Deng WM, Jiang J. 2022. Damage-induced regeneration of the intestinal stem cell pool through enteroblast mitosis in the Drosophila midgut. EMBO J. doi: 10.15252/embj.2022110834

Jevitt A, Huang YC, Zhang SM, Chatterjee D, Wang XF, Xie GQ, Deng WM. 2021. Modeling Notch-Induced Tumor Cell Survival in the Drosophila Ovary Identifies Cellular and Transcriptional Response to Nuclear NICD Accumulation. Cells. doi: 10.3390/cells10092222

Row S, Huang YC, Deng WM. 2021. Developmental regulation of oocyte lipid intake through ‘patent’ follicular epithelium in Drosophila melanogaster. iScience. doi: j.isci.2021.102275.

Bejarano F, Chang CH, Sun K, Hagen JW, Deng WM, Lai EC. 2021. A comprehensive in vivo screen for anti-apoptotic miRNAs indicates broad capacities for oncogenic synergy. Dev Biol. doi: 10.1016/j.ydbio.2021.02.010.

Gong SY, Zhang YC, Bao HC, Wang XF, Chang CH, Huang YC, Deng WM. 2021. Tumor Allotransplantation in Drosophila melanogaster with a Programmable Auto-Nanoliter Injector. JoVE. doi: 10.3791/62229.

Ly PT, Tan YS, Koe CT, Zhang Y, Xie G, Endow S, Deng WM, Yu F, Wang H. 2019. CRL4Mahj E3 Ubiquitin Ligase Promotes Neural Stem Cell Reactivation. PLoS Biol. 17 (6), e3000276

Yang SA, Portilla JM, Mihailovic S, Huang YC, Deng WM. 2019. Oncogenic Notch Triggers Neoplastic Tumorigenesis in a Transition-Zone-like Tissue Microenvironment. Dev Cell. 49 (3), 461-472.e5

Lo PK, Huang YC, Corcoran D, Jiao R, Deng WM. 2019. Inhibition of Notch signaling by the p105 and p180 subunits of Drosophila chromatin assembly factor 1 is required for follicle cell proliferation. J Cell Sci. 132(2):jcs224170.

Yang SA, Deng WM. 2018. Serrate-Notch Signaling Regulates the Size of the Progenitor Cell Pool in Drosophila Imaginal Rings. Genetics. 209(3):829–843.

Huang YC, Moreno H, Row S, Jia D, Deng WM. 2018. Germline silencing of UASt depends on the piRNA pathway. J Genet Genomics. 45(5):273–276.

Shu Z, Huang YC, Palmer WH, Tamori Y, Xie G, Wang H, Liu N, Deng WM. 2017. Systematic analysis reveals tumor-enhancing and -suppressing microRNAs in Drosophila epithelial tumors. Oncotarget. 8 (65):108825-108839

Yan Y, Wang H, Hu M, Jiang L, Wang Y, Liu P, Liang X, Liu J, Li C, Lindstrom-Battle A, Lam SM, Shui G, Deng WM, Jiao R. 2017. HDAC6 Suppresses Age-Dependent Ectopic Fat Accumulation by Maintaining the Proteostasis of PLIN2 in Drosophila. Developmental Cell. 43 (1):99-111

Zouaz A, Auradkar A, Delfini MC, Macchi M, Barthez M, Ela Akoa S, Bastianelli L, Xie G, Deng WM, Levine SS, Graba Y, Saurin AJ. 2017. The Hox proteins Ubx and AbdA collaborate with the transcription pausing factor M1BP to regulate gene transcription. EMBO J. 36(19):2887-2906

Kan L, Grozhik AV, Vedanayagam J, Patil DP, Pang N, Lim KS, Huang YC, Joseph B, Lin CJ, Despic V, Guo J, Yan D, Kondo S, Deng WM, Dedon PC, Jaffrey SR, Lai EC. 2017. The m6A pathway facilitates sex determination in Drosophila. Nature Communication. 8:15737

Shu Z, Deng WM. 2017. Differential Regulation of Cyclin E by Yorkie-Scalloped Signaling in Organ Development. G3. 7(3):1049-1060

Tamori Y, Suzuki E, Deng WM. 2016. Epithelial Tumors Originate in Tumor Hotspots, a Tissue-Intrinsic Microenvironment. PLoS Biol. 1;14(9):e1002537.

Jia D, Bryant J, Jevitt A, Calvin G, Deng WM. 2016. The Ecdysone and Notch Pathways Synergistically Regulate Cut at the Dorsal-Ventral Boundary in Drosophila Wing Discs. J Genet Genomics. 5:12328

Jia D, Xu Q, Mio W, Deng WM. 2016. Automatic stage identification of Drosophila egg chamber based on DAPI images. Scientific Report. 6:18850.

Lo PK, Huang YC, Poulton JS, Leake N, Palmer WH, Vera D, Xie, Klusza S, Deng WM. 2016. RNA helicase Belle/DDX3 regulates transgene expression in Drosophila. Develompental Biology. 412 (1): 57-70

Jia D, Soylemez M, Calvin G, Bornmann R, Bryant J, Hanna C, Huang YC, Deng WM. 2015. A large-scale in vivo RNAi screen to identify genes involved in Notch-mediated follicle cell differentiation and cell cycle switches. Scientific Reports. 5:12328

Zhang H, Li C, Chen H, Wei C, Dai F, Wu H, Dui W, Deng WM, Jiao R. 2015. SCF(Slmb) E3 ligase-mediated degradation of Expanded is inhibited by the Hippo pathway in Drosophila. Cell Research. 25(1):93-109

Palmer WH, Jia D, Deng, WM. 2014. Cis-interactions between Notch and its ligands block ligand-independent Notch activity. eLife. 3:e04415.

Yu Z, Chen H, Liu J, Zhang H, Yan Y, Zhu N, Guo Y, Yang B, Chang Y, Dai F, Liang X, Chen Y, Shen Y, Deng WM, Chen J, Zhang B, Li C, Jiao R. 2014. Various applications of TALEN- and CRISPR/Cas9-mediated homologous recombination to modifytheDrosophilagenome. Biology open. 3(4):271-80.

Xie G, Yu Z, Jia D, Jiao R, Deng WM. 2014. E(y)1/TAF9 mediates the transcriptional output of Notch signaling in Drosophila. Journal of Cell Science. 127(Pt 17):3830-9.

Jia D, Tamori Y, Pyrowolakis G, Deng WM. 2014. Regulation of broad by the Notch pathway affects timing of follicle cell development. Developmental Biology. 392(1): 52-61.

Klusza S, Novak A, Figueroa S, Palmer W, Deng WM. 2013. Prp22 and Spliceosome Components Regulate Chromatin Dynamics in Germ-Line Polyploid Cells. PLoS ONE. 8(11):e79048.

Yu Z, Wu H, Chen H, Wang R, Liang X, Liu J, Li C, Deng WM*, Jiao R.* 2013. CAF-1 promotes Notch signaling through epigenetic control of target gene expression during Drosophila development. Development. 140(17): 3635-4. (*equal contributing co-corresponding authors)

Tamori Y, Deng WM. 2013. Tissue Repair through Cell Competition and Compensatory Cellular Hypertrophy in Postmitotic Epithelia. Developmental Cell. 25(4): 350-363.

Huang YC, Poulton J, Smith L, Deng WM. 2013. The microRNA miR-7 regulates Tramtrack69 in a developmental switch in Drosophila follicle cells. Development. 140(4): 897-905.

Tian AG, Tamori Y, Huang YC, Toledo Melendez N, Deng WM. 2013. Efficient EGFR signaling and dorsal-ventral axis patterning requires syntaxin dependent Gurken trafficking. Developmental Biology. 373(2): 349-58.

Heck BW, Zhang B, Tong X, Deng WM, Tsai CC. 2012. The transcriptional corepressor SMRTER influences both Notch and ecdysone signaling during Drosophila development. Biology open. 1(3): 182-196.

Liu J, Li C, Huang P, Wu H, Wei C, Zhu N, Shen Y, Chen Y, Deng WM*, Jiao R*. 2012. Efficient and Specific Modifications of the Drosophila Genome by Means of an Easy TALEN Strategy. Journal of Genetics and Genomics. 39: 209-215. (*equal contributing co-corresponding authors)

Poulton J, Huang YC, Smith L, Sun JJ, Leake N, Schleede J, Stevens L, Deng WM. 2011. The microRNA pathway regulates the temporal pattern of Notch signaling in Drosophila follicle cells. Development. 138(9): 1737-45.

Tamori Y, Bialucha CU, Tian AG, Kajita M, Huang YC, Norman M, Harrison N, Poulton J, Ivanovitch K, Disch L, Liu T, Deng WM*, Fujita Y*. 2010. Involvement of Lgl and Mahjong/VprBP in Cell Competition. PLoS Biology.doi:10.1371/journal.pbio.1000422 (*equal contributing co-corresponding authors). (#18 in Discover magazine top 100 Stories of 2010)

Klusza S, Deng WM. 2010. poly is required for nurse-cell chromosome dispersal and oocyte polarity in Drosophila. Fly (Austin). 4(2): 128-36.

Yu J, Zheng Y, Dong J, Klusza S, Deng WM *, Pan D *. 2010. Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded. Developmental Cell. 18(2): 288-99. (*equal contributing co-corresponding authors)

Shyu LF, Sun J, Chung HM, Huang YC, Deng WM. 2009. Notch signaling and developmental cell-cycle arrest in Drosophila polar follicle cells. Molecular Biology of the Cell 20(24): 5064-73.

Yatsenko AS, Kucherenko MM, Pantoja M, Fischer KA, Madeoy J, Deng WM, Schneider M, Baumgartner S, Akey J, Shcherbata HR, Ruohola-Baker H. 2009. The conserved WW-domain binding sites in Dystroglycan C-terminus are essential but partially redundant for Dystroglycan function. BMC Developmental Biology. 27: 9-18

Tian AG, Deng WM. 2009. Par-1 and Tau regulate the anterior-posterior gradient of microtubules in Drosophila oocytes. Developmental Biology. 327(2): 458-64.

Cooper E, Deng WM, Chung HM. 2009. Aph-1 is required to regulate Presenilin-mediated gamma-secretase activity and cell survival in Drosophila wing development. Genesis. 47(3): 169-74.

Sun J, Smith L, Armento A, Deng WM. 2008. Regulation of the endocycle/gene amplification switch by Notch and ecdysone signaling. The Journal of Cell Biology. 182(5): 885-96.

Yu J, Poulton J, Huang YC, Deng WM. 2008. The Hippo Pathway Promotes Notch Signaling in Regulation of Cell Differentiation, Proliferation, and Oocyte Polarity. PLoS ONE. 3(3): e1761.

Tian AG, Deng WM. 2008. Lgl and its phosphorylation by aPKC regulate oocyte polarity formation in Drosophila. Development. 135(3):463-71.

Sun J, Deng WM. 2007. Hindsight mediates the role of notch in suppressing hedgehog signaling and cell proliferation. Developmental Cell. 12(3):431-42.

Schneider M, Khalil AA, Poulton J, Castillejo-Lopez C, Egger-Adam D, Wodarz A, Deng WM, Baumgartner S. 2006. Perlecan and Dystroglycan act at the basal side of the Drosophila follicular epithelium to maintain epithelial organization. Development. 133:3805-15.

Poulton J, Deng WM. 2006. Dystroglycan down-regulation links EGF receptor signaling and anterior-posterior polarity formation in the Drosophila oocyte. Proc Natl Acad Sci U S A. 103(34): 12775-80.

Sun J, Deng WM. 2005. Notch-dependent downregulation of the homeodomain gene cut is required for the mitotic cycle/endocycle switch and cell differentiation in Drosophila follicle cells. Development 132: 4299-4308.

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Review Articles & Book Chapters

Chatterjee D, Deng WM. 2023, Standardization of Single-Cell RNA-Sequencing Analysis Workflow to Study Drosophila Ovary. Methods in Molecular Biology. doi.org/10.1007/978-1-0716-3259-8_9

Costa CAM, Wang XF, Ellsworth C, Deng WM. 2021, Polyploidy in development and tumor models in Drosophila. Seminars in Cancer Biology. doi.org/10.1016/j.semcancer.2021.09.011

Gong S, Zhang Y, Tian A, Deng WM. 2021, Tumor models in various Drosophila tissues. WIREs Mechanisms of Disease. doi.org/10.1002/wsbm.1525

Chatterjee D, Deng WM. 2019. Drosophila Model in Cancer: An Introduction. Adv Exp Med Biol. 1167, 1-14

Ji JY, Han C, Deng WM. 2019. Understanding Human Diseases Using Drosophila. Journal of Genetics and Genomics. 46 (4), 155-156.

Shu Z, Row S, Deng WM. 2018. Endoreplication: The Good, the Bad, and the Ugly. Trends in Cell Biology. 28(6):465–474.

Tamori Y, Deng WM. 2017. Tissue-Intrinsic Tumor Hotspots: Terroir for Tumorigenesis. Trends in Cell Biology. 3 (4), 259-268

Ma J, He F, Xie G, Deng WM. 2016. Maternal AP determinants in the Drosophila oocyte and embryo. Wiley Interdisciplinary Reviews: Developmental Biology. 5(5):562-81.

Jia D, Huang YC, Deng WM. 2015. Analysis of Cell Cycle Switches in Drosophila Oogenesis. Methods in Molecular Biology. 1328:207-16.

Palmer WH, Deng WM.2015. Ligand-Independent Mechanisms of Notch Activity. Trends in Cell Biology. 25(11): 697-707.

Tamori Y, Deng WM. 2014. Compensatory cellular hypertrophy: the other strategy for tissue homeostasis. Trends in Cell Biology. 24(4): 230-7.

Deng WM. 2011. Molecular genetics of cancer and tumorigenesis: Drosophila models. Journal of Genetics and Genomics. 38(10): 429-30.

Tamori Y, Deng WM. 2011. Cell competition and its implications for development and cancer. Journal of Genetics and Genomics. 38(10):483-95.

Klusza S, Deng WM. 2011. At the crossroads of differentiation and proliferation: Precise control of cell-cycle changes by multiple signaling pathways in Drosophila follicle cells. Bioessays. 33(2): 124-34.

Poulton J, Deng WM. 2007. Cell-cell communication and axis specification in the Drosophila oocyte. Developmental Biology. 311(1):1-10.

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